Regenerative Medicine Amniotic Fluid Joint Injections

AmnioFlo is processed at Bone Bank Allografts (est. 1993) in Texas. The data on amniotic tissue and fluid goes back over 100 years. Most recent advancements in this space allowed for the processing of the tissue and fluid to be in a stable format that can sit in ambient conditions for years while still retaining all the beneficial factors that we know about this acellular allograft (cytokines, growth factors, hyaluronic acid) that result in moderation of inflammation, accelerated healing, antibacterial properties, reduced fibrosis/scarring and decreased pain. All this plus a very long track record of safety.

References for Bone Bank Allografts Products

• Nyman E, Huss F, Nyman ‘T, Junker J, Kratz G. (2013 Apr) Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: in vitro studies of re-epithelialisation in human skin wounds. J Plast Surg Hand Surg. 47(2):89-92

• Adzick NS, Lorenz HP. (1994 Jul) Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Annals of Surgery;220(1):10-18.

• Gao X, Devoe LD, Given KS. (1994 Aug) Effects of amniotic fluid on proteases: a possible role of amniotic fluid in fetal wound healing. Annals of Plastic Surgery. 33(2):128-134; discussion 134-135.

• Bolat E, Kocamaz E, Kulahcilar Z, Yilmaz A, Topcu A, Ozdemir M, Coskun ME. (2013 Dec) Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J. 7(4):253-9.

• Cobanglu U, Kutlu N, Karacal N, Kosucu P. (2005 Dec) Effect of human amniotic fluid on bone healing, J Surg Res.129(2):283-7.

• Ozgenel GY, Filiz G, Ozcan M. (2004 Jul) Effects of human amniotic fluid on cartilage regeneration from free perichondrial grafts in rabbits. Br J Plast Surg. 57(5):423-8.

References

1. Nyman E, Huss F, Nyman T, Junker J, Kratz G. (2013 Apr) Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: in vitro studies of re-epithelialisation in human skin wounds. J Plast Surg Hand Surg. 47(2):89-92
2. Adzick NS, Lorenz HP. (1994 Jul) Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Annals of Surgery.;220(1):10-18.
3. Gao X, Devoe LD, Given KS. 1994 Aug) Effects of amniotic fluid on proteases: a possible role of amniotic fluid in fetal wound healing. Annals of Plastic Surgery. 332)128-134; discussion 134-135.
4. Bolat E, Kocamaz E, Kulahcilar Z, Yilmaz A, Topcu A, Ozdemir M, Coskun ME. (2013 Dec) Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J. 7(4):253-9.
5. Ozgenel GY, Filiz G, Ozcan M. (2004 Jul) Effects of human amniotic fluid on cartilage regeneration from free perichondrial grafts in rabbits. Br J Plast Surg. 57(5):423-8.
6. Rosner M, Hipany K, Shanmugasundaram B, Lubec G, Hengstschlager M (2012 Jun) Amniotic Fluid Stem Cells: Future Perspectives. Stem Cells Int. 2012: 741810.

Scientific Background and Reference Sources

• Koob TJ, Rennert R, Zabek N, et al. Biological properties of dehydrated human amnion/chorion composite graft implications for chronic wound healing. Int Wound J. Oct 2013;10(5):493-500. PMID 23902526

• Zelen CM, Poka A, Andrews J. Prospective, randomized, blinded, comparative study of injectable micronized dehydrated amniotic/chorionic membrane allograft for plantar fasciitis—a feasibility study. Foot Ankle Int. Oct 2013;34(10):1332-1339. PMID 23945520

Amniotic Tissue Injection

What is Fluid Flow^TM?

Fluid Flow^TM is an amniotic liquid allograft derived from the amniotic fluid within the placenta. It is used by health practitioners to safely and effectively treat soft tissue pain and inflammation, while promoting regeneration of our bodies to their optimal health.

What is Human Amniotic Fluid?

Amniotic fluid is abundant in growth factors and cytokines associated with repair, replacement, and regeneration of soft tissue. When injected into the body, these growth factors and cytokines have been shown to promote healing and pain management.

Is Fluid Flow^TM comfortable?

Yes. The major advantage of the Fluid Flow^TM technology is its ability to effectively treat the condition while enabling the patient to maintain a comfortable, functional, and high-quality lifestyle.

Is Fluid Flow^TM safe?

Yes. The safety and quality of Fluid Flow^TM is carefully controlled. Fluid Flow^TM liquid allograft is processed following stringent FDA regulations and requirements.

What types of conditions are treatable with Fluid Flow^TM?

The biologic components of Fluid Flow^TM are often used as part of a treatment regimen to successfully combat pain and inflammation in soft tissue of the lower extremities. It has been shown to be an excellent modality for treating the symptoms of arthritis, plantar fasciitis, and tendinitis.

What clinical benefits have been shown with Fluid Flow^TM?

The biologic components of Fluid Flow^TM have been shown to reduce inflammation, promote healing, and enhance comfort.

How long has Fluid Flow^TM been used by Healthcare Practitioners?

For several decades, health practitioners around the world have used amniotic liquid allografts to treat a variety of disorders and conditions.

Benefits of Using Fluid Flow^TM

The components of Fluid Flow^TM have been shown to activate the body’s own healing response, which is characterized by minimal inflammatory activity and regenerative rather than scar-mediated healing.

Fluid Flow^TM is composed of a complex array of growth factors and cytokines responsible for the repair, replacement, and regeneration of soft tissue. Because of its inherent anti-inflammatory and anti-scarring properties, these same components have been used clinically as an additive for surgical applications associated with soft tissue procedures.